| 货号 | 15490-5mg |
| 描述 | BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways, inhibiting 5-LO, COX-1, and COX-2 (IC50s = 0.75 μM, 0.65 μg/ml, and 1.2 μg/ml, respectively).1,2,3 It may also inhibit other LO pathways in vivo.4 Through these actions, BW 755C diminishes inflammation.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Aizawa, Y.,Kanai, T.,Hasegawa, K., et al. Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity. Journal of Medicinal Chemistry 33(5), 1491-1496 (1990). 2.Hlasta, D.J.,Casey, F.B.,Ferguson, E.W., et al. 5-Lipoxygenase inhibitors: The synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. Journal of Medicinal Chemistry 34(5), 1560-1570 (1991). 3.Mitchell, J.A.,Akarasereenont, P.,Thiemermann, C., et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proceedings of the National Academy of Sciences of the United States of America 90, 11693-11697 (1993). 4.Tanaka, N.,Espey, L.L.,Kawano, T., et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. American Journal of Physiology 260, E170-E174 (1991). 5.Higgs, G.A.,Flower, R.J. and Vane, J.R. A new approach to anti-inflammatory drugs. Biochemical Pharmacology 28, 1959-1961 (1979). 6.Calhoun, W.,Yu, J.,Sung, A., et al. Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse. Agents and Actions 27, 418-421 (1989). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 229.3 |
| 分子式 | C10H10F3N3 |
| CAS号 | 66000-40-6 |
| 稳定性 | ≥ 2 years |
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