bpV(HOpic) (potassium salt, technical grade)
货号：
15438-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 15438-5mg |
| 描述 | bpV(HOpic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 14 nM).1 It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 4.9 μM), and PTP-1βB (IC50 = 25.3 μM).1 At 15 μM, bpV(HOpic) has been shown to protect against stimulated ischemia-reperfusion injury in vitro by decreasing apoptosis and improving cell viability through the upregulation of the PI3K/Akt/eNOS/ERK prosurvival pathway.2 |
| 别名 | Bisperoxovanadium(HOpic); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schmid, A.C.,Byrne, R.D.,Vilar, R., et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Letters 566(1-3), 35-38 (2004).
2.Keyes, K.T.,Xu, J.,Long, B., et al. Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction. American Journal of Physiology.Heart and Circulatory Physiology 298, H1198-H1208 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥80% |
| 计算分子量 | 347.2 |
| 分子式 | C6H4NO8V • 2K |
| CAS号 | 722494-26-0 |
| 稳定性 | ≥ 2 years |
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