| 货号 | 15407-50mg |
| 描述 | Budesonide is a glucocorticoid steroid that activates the glucorcorticoid receptor with an EC50 value of 12.4 nM.1 Like other glucocorticoids, budesonide reduces inflammation and has utility in inflammatory diseases, like asthma and inflammatory bowel disease.1,2,3,4 Also like other glucocorticoids, budesonide may be abused by athletes.5 |
| 别名 | Entocort;Pulmicort; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Millan, D.S.,Ballard, S.A.,Chunn, S., et al. Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma. Bioorganic & Medicinal Chemistry Letters 21(19), 5826-5830 (2011). 2.Schwartze, J.T.,Becker, S.,Sakkas, E., et al. Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-β signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts. The Journal of Biological Chemisty (2013). 3.Prantera, C. and Marconi, S. Glucocorticosteroids in the treatment of inflammatory bowel disease and approaches to minimizing systemic activity. Therap.Adv.Gastroenterol. 6(2), 137-156 (2013). 4.Ashton, M.J.,Lawrence, C.,Karlsson, J.A., et al. Anti-inflammatory 17β-thioalkyl-16α,17α-ketal and -acetal androstanes: A new class of airway selective steroids for the treatment of asthma. Journal of Medicinal Chemistry 39(25), 4888-4896 (1996). 5.Kiss, A.,Lucio, M.,Fildier, A., et al. Doping control using high and ultra-high resolution mass spectrometry based non-targeted metabolomics - A case study of salbutamol and budesonide abuse. PLoS One 8(9), 1-14 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 430.5 |
| 分子式 | C25H34O6 |
| CAS号 | 51333-22-3 |
| 稳定性 | ≥ 2 years |
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