| 货号 | 15399-1mg |
| 描述 | Xanthohumol is a natural prenylated chalcone isolated from the hop plant, H. lupulus. Xanthohumol and its metabolites induce protective detoxification enzymes, at least in part via the nuclear factor erythroid-2-related factor 2 pathway.1,2 It inhibits phosphoinositide-dependent kinase 1 (IC50 = 6.6 μM) but not PKC in an in vitroassay.3 Xanthohumol also can have anti-inflammatory, antioxidant, anti-carcinogenic, and osteogenic effects.4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Krajka-Kuzniak, V.,Paluszczak, J. and Baer-Dubowska, W. Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro. Toxicol.In Vitro 27(1), 149-156 (2013). 2.Dietz, B.M. and Bolton, J.L. Biological reactive intermediates (BRIs) formed from botanical dietary supplements. Chemico-Biological Interactions 192(1-2), 72-80 (2011). 3.Lauro, G.,Masullo, M.,Piacente, S., et al. Inverse virtual screening allows the discovery of the biological activity of natural compounds. Bioorganic & Medicinal Chemistry 20(11), 3596-3602 (2012). 4.Costa, R.,Negrao, R.,Valente, I., et al. Xanthohumol modulates inflammation, oxidative stress, and angiogenesis in type 1 diabetic rat skin wound healing. Journal of Natural Products 76(11), 2047-2053 (2013). 5.Venè, R.,Benelli, R.,Minghelli, S., et al. Xanthohumol impairs human prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice. Molecular Medicine 18, 1292-1302 (2012). 6.Schilling, T.,Ebert, R.,Raaijmakers, N., et al. Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration. Journal of Steroid Biochemistry and Molecular Biology 139, 252-261 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 354.4 |
| 分子式 | C21H22O5 |
| CAS号 | 6754-58-1 |
| 稳定性 | ≥ 2 years |
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