| 货号 | 15362-1mg |
| 描述 | In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation.1 A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G.1 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM).2 It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation.2 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis.2,3,4 Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders.5,6,7 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.8 |
| 别名 | eIF4E/eIF4G Interaction Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dever, T.E. Gene-specific regulation by general translation factors. Cell 108(4), 545-556 (2002). 2.Moerke, N.J.,Aktas, H.,Chen, H., et al. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128(2), 257-267 (2007). 3.Tamburini, J.,Green, A.S.,Bardet, V., et al. Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. Blood 114(8), 1618-1627 (2009). 4.Chen, L.,Aktas, B.H.,Wang, Y., et al. Tumor suppression by small molecule inhibitors of translation initiation. Oncotarget 3(8), 869-881 (2012). 5.Hoeffer, C.A.,Cowansage, K.K.,Arnold, E.C., et al. Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Proceedings of the National Academy of Sciences of the United States of America 108(8), 3383-3388 (2011). 6.Gkogkas, C.G.,Khoutorsky, A.,Ran, I., et al. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493(7432), 371-377 (2013). 7.Santini, E.,Huynh, T.N.,MacAskill, A.F., et al. Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature 493(7432), 411-415 (2013). 8.Redondo, N.,García-Moreno, M.,Sanz, M.A., et al. Translation of viral mRNAs that do not require eIF4E is blocked by the inhibitor 4EGI-1. Virology 444(1-2), 171-180 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 451.3 |
| 分子式 | C18H12Cl2N4O4S |
| CAS号 | 315706-13-9 |
| 稳定性 | ≥ 2 years |
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