| 货号 | 15361-1mg-Cayman |
| 描述 | Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations.1 It immobilizes ribosomes immediately after the initiation of translation.1,2 While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia.3,4,5 The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation.2 |
| 别名 | NSC 124147; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fresno, M.,Jiménez, A. and Vázquez, D. Inhibition of translation in eukaryotic systems by harringtonine. European Journal of Biochemistry 72(2), 323-330 (1977). 2.Ingolia, N.T.,Brar, G.A.,Rouskin, S., et al. The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nature Protocols 7(8), 1534-1550 (2012). 3.Kantarjian, H.M.,OBrien, S.,Anderlini, P., et al. Treatment of chronic myelogenous leukemia: Current status and investigational options. Blood 87(8), 3069-3081 (1996). 4.Chen, Y.,Peng, C.,Sullivan, C., et al. Novel therapeutic agents against cancer stem cells of chronic myeloid leukemia. Anticancer Agents Med.Chem. 10(2), 111-115 (2010). 5.Robert, F.,Carrier, M.,Rawe, S., et al. Altering chemosensitivity by modulating translation elongation. PLoS One 4(5), e5428 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 531.6 |
| 分子式 | C28H37NO9 |
| CAS号 | 26833-85-2 |
| 稳定性 | ≥ 2 years |
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