ML-335
货号：
15196-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 15196-1mg |
| 描述 | The μ-opioid receptor (OPRM1) is the primary site of action for morphine and other opioids associated with the treatment of pain. The occupancy of δ-opioid receptors (OPRD1) by antagonists has been shown to enhance OPRM1 binding and signaling activity.1 Because heteromerization of OPRM1 and OPRD1 is thought to be a potential mechanism by which this occurs, compounds are being sought that selectively activate OPRM1-OPRD1 heterodimerization while alleviating the unwanted effects associated with prolonged opiate use. ML-335 is the first identified agonist for OPRM1-OPRD1 heterodimerization (EC50 = 403 nM) that demonstrates selectivity over the individual OPRM1 and OPRD1 receptors and the serotonin HT5A receptor (EC50s = 14.9, 1.1, and >40 μM, respectively).1 |
| 别名 | CID-23723457;CYM 51010; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pinello, C.,Guerrero, M.,Eberhart, C., et al. Characterization of an agonist probe for opioid receptor mu 1 (OPRM1)-opioid receptor delta 1 (OPRD1) heterodimerization. 1-14 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 408.5 |
| 分子式 | C25H32N2O3 |
| CAS号 | 1069498-96-9 |
| 稳定性 | ≥ 2 years |
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