| 货号 | 15187-1mg |
| 描述 | The apelin receptor (APJ) signaling pathway mediates cardiovascular homeostasis and is involved in the pathogenesis of cardiovascular diseases.1,2,3,4 ML-233 is a novel APJ agonist (EC50 = 3.7 μM) that is >21-fold selective over the closely related angiotensin 1 receptor (EC50 = >79 μM).5 |
| 别名 | CID-46905036; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tatemoto, K.,Hosoya, M.,Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998). 2.Lee, D.K.,Cheng, R.,Nguyen, T., et al. Characterization of apelin, the ligand for the APJ receptor. Journal of Neurochemistry 74, 34-41 (2000). 3.Kleinz, M.J. and Davenport, A.P. Emerging roles or apelin in biology and medicine. Pharmacology & Therapeutics 107, 198-211 (2005). 4.Scimia, M.C.,Hurtado, C.,Ray, S., et al. APJ acts as a dual receptor in cardiac hypertrophy. Nature 488, 394-398 (2012). 5.Khan, P.,Maloney, P.R.,Hedrick, M., et al. Functional agonists of the apelin J (APJ) receptor. 1-22 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 359.4 |
| 分子式 | C19H21NO4S |
| 稳定性 | ≥ 2 years |
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