ML115
货号：
15178-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 15178-500ug |
| 描述 | Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.1,2 ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB.3 It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6.3 As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.3 |
| 别名 | CID 6619100;SID 14735210; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Poli, V. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. The Journal of Biological Chemisty 273, 29279-29282 (1998).
2.Yu, H. and Jove, R. The stats of cancer - new molecular targets come of age. Nature Reviews.Cancer 4, 97-105 (2004).
3.Madoux, F.,Koenig, M.,Nelson, E., et al. Modulators of STAT transcription factors for the targeted therapy of cancer (STAT3 activators). (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 322.7 |
| 分子式 | C15H15ClN2O4 |
| CAS号 | 912798-42-6 |
| 稳定性 | ≥ 2 years |
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