ML-098
货号：
15175-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 15175-1mg |
| 描述 | The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP. Alterations in GTPase function are a known hallmark of certain cancers and genetic diseases. ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) that demonstrates selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).1 It has been shown to function by increasing the affinity of the GTPase for guanine nucleotides.1 |
| 别名 | CID-7345532; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Surviladze, Z.,Ursu, O.,Miscisocia, F., et al. UNMCMD Probe Report: Three small molecule pan activator families of Ras-related GTPases. 1-42 (2009).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 309.4 |
| 分子式 | C19H19NO3 |
| CAS号 | 878978-76-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
