Ziprasidone (hydrochloride hydrate)
货号：
15031-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 15031-5mg |
| 描述 | Ziprasidone is the hydrochloride salt of a benzisothiazolylpiperazine analog structurally related to the atypical antipsychotic drug tiospirone that antagonizes both central serotonin 5-HT2A(Ki = 0.42 nM) and dopamine D2(Ki = 4.8 nM) receptors.1 It is also a potent agonist at 5-HT1A receptors (Ki = 3.4 nM), increasing cortical dopamine release which may offset negative effects associated with dopamine D2 antagonism, and an inverse agonist at 5-HT1B and 5-HT1D receptors (pKis = 8.8 and 8.6, respectively).2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Prakash, C.,Kamel, A.,Anderson, W., et al. Metabolism and excretion of the novel antipsychotic drug ziprasidone in rats after oral administration of a mixture of 14C- and 3H-labeled ziprasidone. Drug Metabolism and Disposition 25(1), 206-218 (1997).
2.Rollema, H.,Lu, Y.,Schmidt, A.W., et al. 5-HT1A receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biological Psychiatry 48(3), 229-237 (2000).
3.Audinot, V.,Newman-Tancredi, A.,Cussac, D., et al. Inverse agonist properties of antipsychotic agents at cloned, human (h) serotonin (5-HT)1B and h5-HT1D receptors. Neuropsychopharmacology 25(3), 410-422 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 467.4 |
| 分子式 | C21H21ClN4OS • HCl [H2O] |
| CAS号 | 138982-67-9 |
| 稳定性 | ≥ 2 years |
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