| 货号 | 14916-25g |
| 描述 | Protocatechuic acid (PCA) is a dihydroxybenzoic acid phenolic compound found in many edible and medicinal plants. It is a major metabolite of antioxidant polyphenols found in green tea and demonstrates free radical scavenging capability in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity assay (IC50 = 16.3 μM).1,2 It is thought to possess anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities. Dietary administration of PCA dose dependently inhibits in vitro chemical carcinogenesis and exerts pro-apoptotic and anti-proliferative effects in different tissues.3 In studies of tumor cell migration and invasion using mouse melanoma B16/F10 cells, PCA at 0.1-2 mM down-regulated the Ras/Akt/NF-κB pathway by targeting RhoB activation, leading to a reduction of MMP-mediated activity.4 |
| 别名 | NSC 16631;PCA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, X.,Lin, J.,Han, W., et al. Antioxidant ability and mechanism of rhizoma Atractylodes macrocephala. Molecules 17(11), 13457-13472 (2012). 2.Al-Musayeib, N.,Perveen, S.,Fatima, I., et al. Antioxidant, anti-glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis. Molecules 16(12), 10214-10226 (2011). 3.Tanaka, T.,Kojima, T.,Suzui, M., et al. Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: Suppressing effects on tumor development and biomarkers expression of colon tumorigenesis. Cancer Research 53(17), 3908-3913 (1993). 4.Lin, H.H.,Chen, J.H.,Chou, F.P., et al. Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation. British Journal of Pharmacology 162(1), 237-254 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 154.1 |
| 分子式 | C7H6O4 |
| CAS号 | 99-50-3 |
| 稳定性 | ≥ 2 years |
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