Akt Inhibitor X
货号：
14863-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 14863-1mg |
| 描述 | Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM.1 This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM.1 Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thimmaiah, K.N.,Easton, J.B.,Germain, G.S., et al. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. The Journal of Biological Chemisty 280(36), 31924-31935 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 381.3 |
| 分子式 | C20H25ClN2O • HCl |
| CAS号 | 925681-41-0 |
| 稳定性 | ≥ 2 years |
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