| 货号 | 14820-1mg |
| 描述 | Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. It has diverse effects on mammalian cells, most notably inducing cell cycle arrest or apoptosis in a range of cancer cell lines.1,2,3 Cucurbitacin B inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM).4 It suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice.4 Cucurbitacin B blocks the inflammatory response of macrophages treated with lipopolysaccharide.5InDrosophila, it serves as an ecdysteroid receptor antagonist (Kd = 5 µM).6 |
| 别名 | Cuc B;NSC 49451;NSC 144154; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Duangmano, S.,Sae-lim, P.,Suksamrarn, A., et al. Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation. BMC Complementary and Alternative Medicine 12, 185-197 (2012). 2.Dakeng, S.,Duangmano, S.,Jiratchariyakul, W., et al. Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: Reduction of Wnt associated proteins and reduced translocation of falectin-3-mediated ß-catenin to the nucleus. J.Cell Biochem. 113(1), 49-60 (2012). 3.Zhang, M.,Bian, Z.G.,Zhang, Y., et al. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Mol.Med.Rep. 10(6), 2905-2911 (2014). 4.Gupta, P. and Srivastava, S.K. Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. Oncotarget 5(7), 1812-1828 (2014). 5.Kim, M.,Park, S.Y.,Jin, M.L., et al. Cucurbitacin B inhibits immunomodulatory function and the inflammatory response in macrophages. Immunopharmacol.Immunotoxicol. 37(5), 473-480 (2015). 6.Dinan, L.,Whiting, P.,Girault, J.P., et al. Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid recepto. Biochemistry Journal 327, 643-650 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 558.7 |
| 分子式 | C32H46O8 |
| CAS号 | 6199-67-3 |
| 稳定性 | ≥ 2 years |
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