| 货号 | 14743-1mg |
| 描述 | Costunolide is a sesquiterpene lactone that is found naturally in certain plant extracts and in alternative medicine oils. It reduces growth (EC50 = 3-35 μM) and induces apoptosis in assorted cancer cell lines.1,2,3 Costunolide inhibits the activation of Akt (15 μM) in endometriotic epithelial cells and STAT3 activation in THP-1 cells (EC50 = 10 μM).4,5 It also inhibits telomerase activity in NALM-6 cells.1 |
| 别名 | Costus lactone;Melampolide;NSC 106404; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kanno, S.I.,Kitajima, Y.,Kakuta, M., et al. Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells. Biological and Pharmaceutical Bullentin 31(5), 1024-1028 (2008). 2.Liu, C.Y.,Chang, H.S.,Chen, I.S., et al. Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells. Radiat.Oncol. 6, 56 (2011). 3.Lohberger, B.,Rinner, B.,Stuendl, N., et al. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells. PLoS One 8(6), e66300 (2013). 4.Kim, J.H.,Yang, Y.I.,Lee, K.T., et al. Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway. Biological and Pharmaceutical Bullentin 34(4), 580-585 (2011). 5.Butturini, E.,Cavalieri, E.,Carcereri de Prati, A., et al. Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation. PLoS One 6(5), e20174 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 232.3 |
| 分子式 | C15H20O2 |
| CAS号 | 553-21-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |