TG101209
货号：
14696-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 14696-1mg |
| 描述 | TG101209 is a potent inhibitor of the tyrosine kinases janus kinase (JAK) 2, FMS-like tyrosine kinase 3, proto-oncogene RET, and JAK3 (IC50 = 6, 25, 17, and 169 nM, respectively).1 Through these effects, it induces cell cycle arrest and apoptosis in leukemic cell lines and CD45+ myeloma cells.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pardanani, A.,Lasho, T.,Levine, R.L., et al. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia 21(8), 1658-1668 (2007).
2.Ramakrishnan, V.,Kimlinger, T.,Haug, J., et al. TG101209, a novel JAK2 inhibitor, has significant in-vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells. American Journal of Hematology 85(9), 675-686 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 509.7 |
| 分子式 | C26H35N7O2S |
| CAS号 | 936091-14-4 |
| 稳定性 | ≥ 2 years |
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