CYM 50308
货号：
14667-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 14667-1mg |
| 描述 | Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P4 couples to Gαi, Gαo, and Gα12/13 proteins leading to the stimulation of MAPK/ERK signaling pathways, as well as to PLC and Rho-Cdc42 activation, and is thought to contribute to immune responses. CYM 50308 is a novel agonist of SIP4(EC50 = 56 nM) that displays 37-fold selectivity against S1P5(EC50 = 2.1 μM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 μM.1 |
| 别名 | CID-49835928;ML-248; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Urbano, M.,Guerrero, M.,Velaparthi, S., et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorganic & Medicinal Chemistry Letters 21(22), 6739-6745 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 405.5 |
| 分子式 | C20H21F2N3O2S |
| CAS号 | 1345858-76-5 |
| 稳定性 | ≥ 2 years |
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