DBZ
货号：
14627-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 14627-1mg |
| 描述 | γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4.1 The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease.2 DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC50 = 1.7 nM).3 Within 4 hours after a single 100 μM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of Aβ40 by reducing Aβ40 levels by 71%.3 |
| 别名 | Dibenzazepine;YO-01027; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dovey, H.F.,John, V.,Anderson, J.P., et al. Functional γ-secretase inhibitors reduce β-amyloid peptide levels in brain. Journal of Neurochemistry 76, 173-181 (2001).
2.Wolfe, M.S. Therapeutic strategies for Alzheimer’s disease. Nature Reviews.Drug Discovery 1, 859-866 (2002).
3.Milano, J.,McKay, J.,Dagenais, C., et al. Modulation of notch processing by γ-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicological Sciences 82(1), 341-358 (2004).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 463.5 |
| 分子式 | C26H23F2N3O3 |
| CAS号 | 209984-56-5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
