| 货号 | 14619-25mg |
| 描述 | Amisulpride is a potent and selective antagonist of the dopamine receptors D2 and D3(Ki = 2.8 and 3.2 nM, respectively, for the human receptors).1 It has no or low activity at numerous other receptors and channels.1 Amisulpride has found use as an antipsychotic in schizophrenia and related illnesses.2,3 It is also a potent antagonist of the serotonin (5-HT) receptors 5-HT2B and 5-HT7(Ki = 13, 11.5 nM, respectively), with the latter effect thought to explain the antidepressant actions of amisulpride.4 |
| 别名 | DAN 2163;Solian; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schoemaker, H.,Claustre, Y.,Fage, D., et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. Journal of Pharmacology and Experimental Therapeutics 280(1), 83-97 (1997). 2.Lepping, P.,Sambhi, R.S.,Whittington, R., et al. Clinical relevance of findings in trials of antipsychotics: Systematic review. British Journal of Psychiatry 198(5), 341-345 (2011). 3.Rummel-Kluge, C.,Komossa, K.,Schwarz, S., et al. Second-generation antipsychotic drugs and extrapyramidal side effects: A systematic review and meta-analysis of head-to-head comparisons. Schizophr.Bull. 38(1), 167-177 (2012). 4.Abbas, A.I.,Hedlund, P.B.,Huang, X.P., et al. Amisulpride is a potent 5-HT7 antagonist: Relevance for antidepressant actions in vivo. Psychopharmacology (Berl) 205(1), 119-128 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 369.5 |
| 分子式 | C17H27N3O4S |
| CAS号 | 71675-85-9 |
| 稳定性 | ≥ 2 years |
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