| 货号 | 14587-1mg |
| 描述 | 9-cis-Retinoic acid is a natural metabolite of vitamin A, derived from the intermediate all-trans retinoic acid (Item No. 11017).1 It potently activates all isoforms of retinoic acid receptor (RAR) (Ki = 0.5-27 nM) as well as retinoid X receptor (RXR) isoforms (Ki = 3.8-12 nM).2,3 RAR heterodimerizes with RXR, while RXR can homodimerize as well as heterodimerize with numerous partners in addition to RAR, thus allowing 9-cis-retinoic acid to evoke a wide range of effects.4,1 |
| 别名 | Alitretinoin;NSC 659772;Panretin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kane, M.A. Analysis, occurrence, and function of 9-cis-retinoic acid. Biochimica et Biophysica Acta 1821(1), 10-20 (2012). 2.Wong, M.F.,Repa, J.J.,Clagett-Dame, M., et al. Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues. Bioorganic & Medicinal Chemistry Letters 7(17), 2313-2318 (1997). 3.Umemiya, H.,Fukasawa, H.,Ebisawa, M., et al. Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. Journal of Medicinal Chemistry 40(26), 4222-4234 (1997). 4.Dawson, M.I. and Xia, Z. The retinoid X receptors and their ligands. Biochim Biophys.Acta. 1821(1), 21-56 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 300.4 |
| 分子式 | C20H28O2 |
| CAS号 | 1241893 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |