I-CBP112 (hydrochloride)
货号：
14468-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 14468-1mg |
| 描述 | cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.1,2 Both CBP and EP300 contain bromodomains, which mediate their binding to acetylated lysine residues on histones and other proteins.3 I-CBP112 is a selective inhibitor of CBP and EP300 that directly binds their bromodomains (Kds = 0.142 and 0.625 μM, respectively). Developed by the Structural Genomics Consortium (SGC), this compound shows only weak cross-reactivity with the bromodomains of bromodomain and extra-terminal proteins and shows no interaction with other bromodomains. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Iyer, N.G.,Özdag, H. and Caldas, C. p300/CBP and cancer. Oncogene 23, 4225-4231 (2004).
2.Kalkhoven, E. CBP and p300: HATs for different occasions. Biochemical Pharmacology 68, 1145-1155 (2004).
3.Zeng, L.,Zhang, Q.,Gerona-Navarro, G., et al. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure 16(4), 643-652 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 505.1 |
| 分子式 | C27H36N2O5 • HCl |
| 稳定性 | ≥ 2 years |
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