MKT-077
货号：
14395-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 14395-1mg |
| 描述 | MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones.1 It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.2,3 |
| 别名 | FJ-776; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Li, X.,Srinivasan, S.R.,Connarn, J., et al. Analogs of the allosteric heat shock protein 70 (Hsp70) inhibitor, MKT-077, as anti-cancer agents. ACS Med.Chem.Lett. 4(11), (2013).
2.Rousaki, A.,Miyata, Y.,Jinwal, U.K., et al. Allosteric drugs: The interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of Molecular Biology 411(3), 614-632 (2011).
3.Wadhwa, R.,Sugihara, T.,Yoshida, A., et al. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Research 60(24), 6818-6821 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 432 |
| 分子式 | C21H22N3OS2 • Cl |
| CAS号 | 147366-41-4 |
| 稳定性 | ≥ 2 years |
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