Thiazovivin
货号：
14245-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 14245-1mg |
| 描述 | Rho-associated kinase (ROCK) is a serine-threonine kinase known to play an important role in Rho-mediated cytoskeleton remodeling and contractile force generation. Down-regulation of ROCK signaling has been shown to enable the cell-adhesion interactions necessary for maintaining human embryonic stem cell survival and self-renewal.1 Thiazovivin is a selective, cell-permeable small molecule that inhibits ROCK activity at a concentration 2 µM.1 It promotes the survival of induced pluripotent stem cells and improves their reprogramming efficiency from human fibroblasts more than 200 fold when used in combination with the ALK5 inhibitor SB 431542 (Item No. 13031) and the MEK inhibitor PD0325091 (Item No. 13034).2 |
| 别名 | Tzv; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Xu, Y.,Zhu, X.,Hahm, H.S., et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proceedings of the National Academy of Sciences of the United States of America 107(18), 8129-8134 (2010).
2.Lin, T.,Ambasudhan, R.,Yuan, X., et al. A chemical platform for improved induction of human iPSCs. Nature Methods 6(11), 805-808 (2009).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 311.4 |
| 分子式 | C15H13N5OS |
| CAS号 | 1226056-71-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
