| 货号 | 14157-500mg |
| 描述 | The polymyxins are cationic peptides originally isolated from B. polymyxa.1 They bind and kill Gram-negative bacteria.2 The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 (Item No. 14074) and B2 being the two major components.3,4 Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa,A. baumannii, and K. pneumoniae.4 |
| 别名 | Aerosporin;Mastimyxin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Falagas, M.E. and Kasiakou, S.K. Toxicity of polymyxins: A systematic review of the evidence from old and recent studies. Critical Care 10(1), (2006). 2.Hancock, R.E.W. Cationic peptides: Effectors in innate immunity and novel antimicrobials. Lancet Infect.Dis. 1(3), 156-164 (2001). 3.Tam, V.H.,Cao, H.,Ledesma, K.R., et al. In vitro potency of various polymyxin B components. Antimicrobial Agents and Chemotherapy 55(9), 4490-4491 (2011). 4.Zavascki, A.P.,Goldani, L.Z.,Li, J., et al. Polymyxin B for the treatment of multidrug-resistant pathogens: A critical review. Journal of Antimicrobial Chemotherapy 60, 1206-1215 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1301.6 |
| 分子式 | C56H98N16O13 • H2SO4 |
| CAS号 | 1405-20-5 |
| 稳定性 | ≥ 2 years |
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