OAC3
货号：
14104-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 14104-5mg |
| 描述 | Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.1,2 OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.3 In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Niwa, H.,Miyazaki, J.i. and Smith, A.G. Quantitative expression of Oct-¾ defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genetics 24(4), 372-376 (2000).
2.Takahashi, K.,Tanabe, K.,Ohnuki, M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
3.Li, W.,Tian, E.,Chen, Z.X., et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proceedings of the National Academy of Sciences of the United States of America 109(51), 20853-20858 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 254.3 |
| 分子式 | C15H11FN2O |
| CAS号 | 182564-41-6 |
| 稳定性 | ≥ 2 years |
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