OAC2
货号：
14103-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 14103-5mg |
| 描述 | Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.1,2 OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.3 In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.3 The iPSCs developed using OAC2 retain the capacity for pluripotent differentiation, whether evaluated in vitroorin vivo.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Niwa, H.,Miyazaki, J.i. and Smith, A.G. Quantitative expression of Oct-¾ defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genetics 24(4), 372-376 (2000).
2.Takahashi, K.,Tanabe, K.,Ohnuki, M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
3.Li, W.,Tian, E.,Chen, Z.X., et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proceedings of the National Academy of Sciences of the United States of America 109(51), 20853-20858 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 236.3 |
| 分子式 | C15H12N2O |
| CAS号 | 6019-39-2 |
| 稳定性 | ≥ 2 years |
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