| 货号 | 14003-1mg |
| 描述 | Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively).1,2 It also reversibly inhibits γ-glutamyl transpeptidase.3,4 Acividin has been used to elucidate aspects of glutathione metabolism and has known anti-tumorigenic activity.5,6,2,7 |
| 别名 | Antibiotic AT-125;NSC 163501;U 42126; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tso, J.Y.,Bower, S.G. and Zalkin, H. Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(αS, 5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125). The Journal of Biological Chemisty 255(14), 6734-6738 (1980). 2.Lyons, S.D.,Sant, M.E. and Christopherson, R.I. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. The Journal of Biological Chemisty 265(19), 11377-11381 (1990). 3.Stole, E.,Smith, T.K.,Manning, J.M., et al. Interaction of γ-glutamyl transpeptidase with acivicin. The Journal of Biological Chemisty 269(34), 21435-21439 (1994). 4.Smith, T.K.,Ikeda, Y.,Fujii, J., et al. Different sites of acivicin binding and inactivation of γ-glutamyl transpeptidases. Proceedings of the National Academy of Sciences of the United States of America 92, 2360-2364 (1995). 5.Griffith, O.W. and Meister, A. Excretion of cysteine and γ-glutamylcysteine moieties in human and experimental animal γ-glutamyl transpeptidase deficiency. Proceedings of the National Academy of Sciences of the United States of America 77(6), 3384-3387 (1980). 6.Meck, R.A.,Clubb, K.J.,Allen, L.M., et al. Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, acivicin (NSC 163501). Cancer Research 41, 4547-4553 (1981). 7.Willoughby, L.F.,Schlosser, T.,Manning, S.A., et al. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Dis.Model Mech. (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 178.6 |
| 分子式 | C5H7ClN2O3 |
| CAS号 | 42228-92-2 |
| 稳定性 | ≥ 2 years |
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