| 货号 | 13999-5mg |
| 描述 | Cafestol is a natural diterpene which is abundant in unfiltered coffee.1,2 It elevates serum cholesterol and triglycerides in humans, an effect which does not seem to occur in monkeys, hamsters, rats, or gerbils.3,4 Dietary cafestol does increase total cholesterol and triglycerides in ApoE3Leiden mice, an effect which is associated with selective activation of farnesoid X receptors and pregnane X receptors.5 Cafestol (20 μM) also inhibits the proliferation of human umbilical vein endothelial cells and prevents their migration and tube formation on Matrigel™.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lam, L.K.T.,Sparnins, V.L. and Wattenberg, L.W. Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse. Cancer Research 42, 1193-1198 (1982). 2.Naidoo, N.,Chen, C.,Rebello, S.A., et al. Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore, Indonesia and India and associations with blood lipids: A survey and cross sectional study. Nutr.J. 10(48), (2011). 3.Urgert, R.,Schulz, A.G.M. and Katan, M.B. Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans. American Journal of Clinical Nutrition 61, 149-154 (1995). 4.de Roos, B.,Sawyer, J.K.,Katan, M.B., et al. Validity of animal models for the cholesterol-raising effects of coffee diterpenes in human subjects. Proceedings of the Nutrition Society 58(3), 551-557 (1999). 5.Ricketts, M.L.,Boekschoten, M.V.,Kreeft, A.J., et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Molecular Endocrinology 21(7), 1603-1616 (2007). 6.Wang, S.,Yoon, Y.C.,Sung, M.J., et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications 421(3), 567-571 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 316.4 |
| 分子式 | C20H28O3 |
| CAS号 | 469-83-0 |
| 稳定性 | ≥ 2 years |
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