| 货号 | 13940-100mg |
| 描述 | Nervonic acid (24:1n-9) is a very long chain fatty acid produced by elongation of oleic acid (18:1n-9) (Item No. 90260) and derived from erucic acid (22:1n-9) (Item No. 90175).1 It is enriched in nervous tissue and is particularly abundant in sphingolipids, such as sphingomyelin in the myelin sheath of nerve fibers.2 Nervonic acid is poorly produced in demyelinating disorders, including multiple sclerosis and adrenoleukodystrophy, suggesting that dietary supplementation may be beneficial.3 In addition, it is deficient in mice which are homozygous for the quaking mutation, a model of Parkinson’s disease.4,5 Nervonic acid also binds and inhibits DNA polymerase β (Ki = 4.0 uM) and HIV-1 reverse transcriptase (Ki = 1.2 uM).6 |
| 别名 | Selacholeic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Taylor, D.C.,Francis, T.,Guo, Y., et al. Molecular cloning and characterization of a KCS gene from Cardamine graeca and its heterologous expression in Brassica oilseeds to engineer high nervonic acid oils for potential medical and industrial use. Plant Biotechnol.J. 7, 925-938 (2009). 2.Hirvisalo, E.L. and Renkonen, O. Composition of human serum sphingomyelins. Journal of Lipid Research 11, 54-59 (1970). 3.Sargent, J.R.,Coupland, K. and Wilson, R. Nervonic acid and demyelinating disease. Medical Hypotheses 42, 237-242 (1994). 4.Baumann, N.A.,Jacque, C.M.,Pollet, S.A., et al. Fatty acid and lipid composition of the brain of a myelin deficient mutant, the "quaking" mouse. European Journal of Biochemistry 4, 340-344 (1968). 5.Cook, C.,Barnett, J.,Coupland, K., et al. Effects of feeding Lunaria oil rich in nervonic and erucic acids on the fatty acid compositions of sphingomyelins from erythrocytes, liver, and brain of the quaking mouse mutant. Lipids 33(10), 993-1000 (1998). 6.Kasai, N.,Mizushina, Y.,Sugawara, F., et al. Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase β and HIV-1 reverse transcriptase. Journal of Biochemistry 132, 819-828 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 366.6 |
| 分子式 | C24H46O2 |
| CAS号 | 506-37-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |