FIPI
货号：
13563-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 13563-1mg |
| 描述 | Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1(IC50 = 25 nM) and PLD2(IC50 = 20 nM).1,2 It also prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.1 FIPI has good pharmacokinetic parameters in rats, with a half-life greater than five hours, a Cmax that, at 363 nM, is greater than 10-fold the IC50versusPLD2, and bioavailability of 18%.2 |
| 别名 | 5-Fluoro-2-Indolyl des-Chlorohalopemide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Su, W.,Yeku, O.,Olepu, S., et al. 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Molecular Pharmacology 75(3), 437-446 (2009).
2.Monovich, L.,Mugrage, B.,Quadros, E., et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorganic & Medicinal Chemistry Letters 17, 2310-2311 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 421.5 |
| 分子式 | C23H24FN5O2 |
| CAS号 | 939055-18-2 |
| 稳定性 | ≥ 2 years |
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