| 货号 | 13527-500ug |
| 描述 | Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities,1 consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo.2,3,4 |
| 别名 | PAB; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, E.,Clark, A.M., and Hufford, C.D. Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi. Journal of Natural Products 58(1), 57-67 (1995). 2.Gong, X.,Wang, M.,Tashiro, S.i., et al. Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death. Experimental and Molecular Medicine 38(4), 428-434 (2006). 3.Wong, V.K.W.,Chiu, P.,Chung, S.S.M., et al. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo. Clinical Cancer Research 11(16), 6002-6011 (2005). 4.Li, M.H.,Miao, Z.H.,Tan, W.F., et al. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1α by promoting proteasome-mediated degradation. Clinical Cancer Research 10, 8266-8274 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 432.5 |
| 分子式 | C23H28O8 |
| CAS号 | 82508-31-4 |
| 稳定性 | ≥ 2 years |
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