CGP 57380
货号：
13322-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 13322-1mg |
| 描述 | CGP 57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro(IC50 = 2.2 μM),1 with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. It blocks the phosphorylation of eIF4E in response to TNF-α, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC50 = 3 μM).1 CGP 57380 also dose-dependently inhibits TNF-α production in RAW 264.7 cells that have been co-treated with agonists for Toll-like receptor (TLR)2 (HKLM), TLR4 (LPS), TLR6/2 (FSL), TLR7 (imiquimod), or TLR9 (CpG DNA), presumably by inhibiting MNK1.2 |
| 别名 | MNK1 Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Knauf, U.,Tschopp, C., and Gram, H. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Molecular and Cellular Biology 21(16), 5500-5511 (2001).
2.Rowlett, R.M.,Chrestensen, C.A.,Nyce, M., et al. MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. American Journal of Physiology and Gastrointestinal Liver Physiology 294, 452-459 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 244.2 |
| 分子式 | C11H9FN6 |
| CAS号 | 522629-08-9 |
| 稳定性 | ≥ 2 years |
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