| 货号 | 13089-500ug |
| 描述 | Radicicol is a natural product derived from D. chlamydosporia with antibiotic, antifungal, and antimalarial properties. It binds and inhibits heat shock protein 90 (Hsp90) with nanomolar affinity.1 This interaction inhibits p23 from associating with Hsp90,2 suppresses signaling through HIF-1α,3 and produces decreased levels of progesterone receptor, Raf-1, p185erb82, and mutant p53.2 Radicicol also binds to and inhibits DNA topoisomerase type II proteins4 and GRP945 through an ATPase domain common to Hsp90. |
| 别名 | KF9-A;KF58332;Monorden;NSC 294404; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sharma, S.V.,Agatsuma, T., and Nakano, H. Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol. Oncogene 16, 2639-2645 (1998). 2.Schulte, T.W.,Akinaga, S.,Soga, S., et al. Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biological activities with geldanamycin. Cell Stress and Chaperones 3(2), 100-108 (1998). 3.Hur, E.,Kim, H.H.,Choi, S.M., et al. Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1 α/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol. Molecular Pharmacology 62(5), 975-982 (2002). 4.Gadelle, D.,Bocs, C.,Graille, M., et al. Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol. Nucleic Acids Research 33(7), 2310-2317 (2005). 5.Corbett, K.D., and Berger, J.M. Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol. Nucleic Acids Research 34(15), 4269-4277 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.7 |
| 分子式 | C18H17ClO6 |
| CAS号 | 12772-57-5 |
| 稳定性 | ≥ 2 years |
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