| 货号 | 11911-25g |
| 描述 | Nonacetylated (e.g., sodium salicylate) and acetylated (aspirin) forms of salicylate are widely used to target inflammation in the treatment of insulin resistance, type 2 diabetes, or rheumatic pain.1 Salsalate is a dimeric prodrug comprising two esterified salicylate moieties. It is advantageous over sodium salicylate because it is insoluble at the acid pH of the stomach and passes suspended but undissolved into the small intestine, sparing the gastric mucosa direct contact.2 Proof-of-principle clinical studies demonstrate that 3-4.5 g/d salsalate can reduce blood glucose, triglyceride, free fatty acid and C-reactive protein concentrations, improve glucose utilization, and increase circulating insulin and adiponectin concentrations in obese adults at risk for the development of type 2 diabetes as well as for patients with type 2 diabetes.3,4,2 |
| 别名 | Disalcid;Nobacid;NSC 49171;Salflex;Salina;Sasapirin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hawley, S.A.,Fullerton, M.D.,Ross, F.A., et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 336, 918-922 (2012). 2.Goldfine, A.B.,Silver, R.,Aldhahi, W., et al. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin.Transl.Sci. 1(1), 36-43 (2008). 3.Goldfine, A.B.,Fonseca, V.,Jablonski, K.A., et al. The effects of salsalate on glycemic control in patients with type 2 diabetes: A randomized trial. Ann Intern Med. 152(6), 346-357 (2010). 4.Fleischman, A.,Shoelson, S.E.,Bernier, R., et al. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 31(2), 289-294 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 258.2 |
| 分子式 | C14H10O5 |
| CAS号 | 552-94-3 |
| 稳定性 | ≥ 2 years |
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