| 货号 | 11852-25mg |
| 描述 | Kaempferol is a flavonoid which is abundant in a variety of plant leaves and fruits. It has diverse physiological activities through both direct and indirect effects.1,2 For example, kaempferol directly binds estrogen receptors α and β, acting as an inverse agonist or agonist.3,4 It also acts as an antioxidant, which presumably contributes to its ability to suppress advanced glycation endproduct-induced NADPH oxidase, NF-κB signaling, and hypoxia-inducible factor-related angiogenesis and VEGF expression.5,6 Kaempferol also suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.7,8,2 |
| 别名 | Nimbecetin;NSC 407289;NSC 656277;Pelargidenon;Rhamnolutein;Swartziol;Trifolitin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Calderón-Montaño, J.M.,Burgos-Morón, E.,Pérez-Guerrero, C., et al. A review on the dietary flavonoid kaempferol. Mini Rev.Med.Chem. 11, 298-344 (2011). 2.Aiyer, H.S.,Warri, A.M.,Woode, D.R., et al. Influence of berry polyphenols on receptor signaling and cell-death pathways: Implications for breast cancer prevention. Journal of Agricultural and Food Chemistry 1-16 (2012). 3.Wang, J.,Fang, F.,Huang, Z., et al. Kaempferol is an estrogen-related receptor α and γ inverse agonist. FEBS Letters 583(4), 643-647 (2009). 4.Guo, A.J.,Choi, R.C.,Zheng, K.Y., et al. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chin.Med. 7, 1-7 (2012). 5.Kim, J.M.,Lee, E.K.,Kim, D.H., et al. Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase. Age (Dordr) 32(2), 197-208 (2010). 6.Luo, H.,Rankin, G.O.,Liu, L., et al. Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutrition and Cancer 61(4), 554-563 (2009). 7.Kumamoto, T.,Fujii, M., and Hou, D.X. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Letters 275, 17-26 (2009). 8.Labbé, D.,Provençal, M.,Lamy, S., et al. The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration. Journal of Nutrition 139(4), 646-652 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 286.2 |
| 分子式 | C15H10O6 |
| CAS号 | 520-18-3 |
| 稳定性 | ≥ 2 years |
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