Tipifarnib
货号：
11747-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 11747-1mg |
| 描述 | Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM).1 It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitroandin vivo tumor models.2,3 |
| 别名 | R 115777; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bell, I.M. Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy? J. Med. Chem. 47(8), 1869-1878 (2004).
2.Vigil, D.,Cherfils, J.,Rossman, K.L., et al. Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy? Nature Reviews.Cancer 10(12), 842-857 (2010).
3.Appels, N.M.G.M.,Beijnen, J.H., and Schellens, J.H.M. Development of farnesyl transferase inhibitors: A review. Oncologist 10, 565-578 (2005).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 489.4 |
| 分子式 | C27H22Cl2N4O |
| CAS号 | 192185-72-1 |
| 稳定性 | ≥ 2 years |
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