| 货号 | 11742-1mg |
| 描述 | Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.1 Neoandrographolide has been shown to inhibit LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM).2 At 25 µM, it can reduce VEGF-induced proliferation of human umbilical vein endothelial cells.3 Neoandrographolide also inhibits the pro-protein convertase furin with an IC50 value of 53.5 µM.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jarukamjorn, K., and Nemoto, N. Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolide. J.Health Sci. 54(4), 370-381 (2008). 2.Batkhuu, J.,Hattori, K.,Takano, F., et al. Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculata. Biological and Pharmaceutical Bullentin 25(9), 1169-1174 (2002). 3.Gong, C.,Xu, C.,Ji, L., et al. A novel semi-synthetic andrographolide analogue A5 inhibits tumor angiogenesis via blocking the VEGFR2-p38/ERK1/2 signal pathway. Biosci.Trends 7(5), 230-236 (2013). 4.Basak, A.,Cooper, S.,Roberge, A.G., et al. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochemistry Journal 338(Pt 1), 107-113 (1999). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 480.6 |
| 分子式 | C26H40O8 |
| CAS号 | 27215-14-1 |
| 稳定性 | ≥ 2 years |
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