Atazanavir
货号：
11733-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 11733-1mg |
| 描述 | Atazanavir is an inhibitor of HIV-1 protease (EC50 = 2.6 nM).1 In isolated cells, it has additive to moderately synergistic antiviral effects when combined with other antiretroviral drugs.1 As a result, it is commonly used in vivo in combination therapy for HIV-1 infection.2 Atazanavir competitively inhibits UDP-gluronosyltransferase, which conjugates bilirubin for clearance, leading to hyperbilirubinemia in a significant portion of those receiving atazanavir therapy.3 |
| 别名 | BMS 232632;CGP 73547;Reyataz®; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Robinson, B.S.,Riccardi, K.A.,Gong, Y.F., et al. BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents. Antimicrobial Agents and Chemotherapy 44(8), 2093-2099 (2000).
2.Boyd, S.D. A review of recommendations and treatment options regarding the management of HIV infection. Am.J.Health Syst.Pharm. 68(11), 991-1001 (2011).
3.Michaud, V.,Bar-Magen, T.,Turgeon, J., et al. The dual role of pharmacogenetics in HIV treatment: Mutations and polymorphisms regulating antiretroviral drug resistance and disposition. Pharmacological Reviews 64(3), 803-833 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 704.9 |
| 分子式 | C38H52N6O7 |
| CAS号 | 198904-31-3 |
| 稳定性 | ≥ 2 years |
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