Coumestrol
货号：
11730-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 11730-1mg |
| 描述 | Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, Item No. 10006315) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells.1,2 Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).3 |
| 别名 | NSC 22842; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chen, H.Y.,Dykstra, K.D.,Birzin, E.T., et al. Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity. Bioorganic & Medicinal Chemistry Letters 14(6), 1417-1421 (2004).
2.Hopert, A.C.,Beyer, A.,Frank, K., et al. Characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model. Environmental Health Perspectives 106(9), 581-586 (1998).
3.Wang, H.,Li, H.,Moore, L.B., et al. The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Molecular Endocrinology 22(4), 838-857 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 268.2 |
| 分子式 | C15H8O5 |
| CAS号 | 479-13-0 |
| 稳定性 | ≥ 2 years |
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