| 货号 | 11710-25mg |
| 描述 | Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 µM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1,2 Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan.1 It does not alter COX activity.3 It is mildly effective in ameliorating osteoarthritis.4,5 |
| 别名 | DAR;4,5-Diacetylrhein;SF 277; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Domagala, F.,Martin, G.,Bogdanowicz, P., et al. Inhibition of interleukin-1β-induced activation of MEK/ERK pathway and DNA binding of NF-κB and AP-1: Potential mechanism for Diacerein effects in osteoarthritis. Biorheology 43(3-4), 577-587 (2006). 2.Boileau, C.,Tat, S.K.,Pelletier, J.P., et al. Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: A possible mechanism for a protective effect against subchondral bone remodelling. Arthritis Research & Therapy 10(3), R71 (2008). 3.Spencer, C.M., and Wilde, M.I. Diacerein. Drugs 53(1), 98-106 (1997). 4.Fidelix, T.S.,Macedo, C.R.,Maxwell, L.J., et al. Diacerein for osteoarthritis. Cochrane Database Syst.Rev. 2014(2), 1-71 (2014). 5.Shin, K.,Kim, J.W.,Moon, K.W., et al. The efficacy of diacerein in hand osteoarthritis: A double-blind, randomized, placebo-controlled study. Clinical Therapeutics 35(4), 431-439 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.3 |
| 分子式 | C19H12O8 |
| CAS号 | 13739-02-1 |
| 稳定性 | ≥ 2 years |
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