| 货号 | 11697-1mg |
| 描述 | The peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation.1,2,3 GW 6471 is an antagonist of PPARα (IC50 = 240 nM).4 It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor.4 GW 6471 is used in cell-free, cell lysate, and whole cell systems to examine the impact of PPARα antagonism.5,6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kersten, S.,Desvergne, B., and Wahli, W. Roles of PPARs in health and disease. Nature 405, 421-424 (2000). 2.Tenenbaum, A.,Motro, M., and Fisman, E.Z. Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: The bezafibrate lessons. Cardiovascular Diabetology 4(14), 1-5 (2005). 3.Ahmed, W.,Ziouzenkova, O.,Brown, J., et al. PPARs and their metabolic modulation: New mechanisms for transcriptional regulation? Journal of Internal Medicine 262, 184-198 (2007). 4.Xu, H.E.,Stanley, T.B.,Montana, V.G., et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα. Nature 415(6873), 813-817 (2002). 5.Wang, W.,Lin, Q.,Lin, R., et al. PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. Experimental Cell Research 319(10), 1523-1533 (2013). 6.Downer, E.J.,Clifford, E.,Amu, S., et al. The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α. The Journal of Biological Chemisty 287(30), 25440-25453 (2012). 7.Müller, M.Q.,de Koning, L.I.,Schmidt, A., et al. An innovative method to study target protein-drug interactions by mass spectrometry. Journal of Medicinal Chemistry 52(9), 2875-2879 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 619.7 |
| 分子式 | C35H36F3N3O4 |
| CAS号 | 880635-03-0 |
| 稳定性 | ≥ 2 years |
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