| 货号 | 11589-1mg |
| 描述 | The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival.1,2 IC-87114 is a cell-permeable selective inhibitor of the PI3K catalytic subunit p110δ (IC50 = 0.5 μM).3 It less effectively inhibits p110γ and p110β (IC50 = 29 and 75 μM, respectively) and has no significant effect on p110α and several other kinases.3,4 This product is used to elucidate the role of p110δ in cells, including neutrophils, natural killer cells, and other types of leukocytes.3,4,5,6,7 It has also been used in mice.8 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hennessy, B.T.,Smith, D.L.,Ram, P.T., et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nature Reviews.Drug Discovery 4, 988-1004 (2005). 2.Hirsch, E.,Ciraolo, E.,Ghigo, A., et al. Taming the PI3K team to hold inflammation and cancer at bay. Pharmacology & Therapeutics 118, 192-205 (2008). 3.Sadhu, C.,Masinovsky, B.,Dick, K., et al. Essential role of phosphoinositide 3-kinase δ in neutrophil directional movement. Journal of Immunology 170(5), 2647-2654 (2003). 4.Sadhu, C.,Dick, K.,Tino, W.T., et al. Selective role of PI3Kδ in neutrophil inflammatory responses. Biochemical and Biophysical Research Communications 308(4), 764-769 (2003). 5.Saudemont, A.,Garçon, F.,Yadi, H., et al. p110γ and p110δ isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease. Proceedings of the National Academy of Sciences of the United States of America 106(14), 5795-5800 (2009). 6.Niedermeier, M.,Hennessy, B.T.,Knight, Z.A., et al. Isoform-selective phosphoinositide 3-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: A novel therapeutic approach. Blood 113(22), 5549-5557 (2009). 7.Sujobert, P.,Bardet, V.,Cornillet-Lefebvre, P., et al. Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood 106(3), 1063-1066 (2005). 8.Lee, K.S.,Lee, H.K.,Hayflick, J.S., et al. Inhibition of phosphoinositide 3-kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. The FASEB Journal 20(3), 455-465 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.4 |
| 分子式 | C22H19N7O |
| CAS号 | 371242-69-2 |
| 稳定性 | ≥ 2 years |
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