Letrozole
货号：
11568-10mg 基本售价：
490.0 元 规格：
10 mg
产品信息
概述| 货号 | 11568-10mg |
| 描述 | Aromatase is a cytochrome P450 family member (designated CYP19) which catalyzes the conversion of androgens to estrogens.1 It may also be called estrogen synthase or estrogen synthetase. Letrozole is a potent, cell-permeable inhibitor of aromatase (IC50 = 2 nM).2 Formulations containing letrozole are prescribed for the treatment of postmenopausal breast cancer.3 |
| 别名 | CGS 20267;Femara; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Buzdar, A.U.,Robertson, J.F.R.,Eiermann, W., et al. An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane. Cancer 95(9), 2006-2016 (2002).
2.Mayhoub, A.S.,Marler, L.,Kondratyuk, T.P., et al. Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. Bioorganic & Medicinal Chemistry 20(7), 2427-2434 (2012).
3.Cohen, M.H.,Johnson, J.R.,Li, N., et al. Approval summary: Letrozole in the treatment of postmenopausal women with advanced breast cancer. Clinical Cancer Research 8(3), 665-669 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 285.3 |
| 分子式 | C17H11N5 |
| CAS号 | 112809-51-5 |
| 稳定性 | ≥ 2 years |
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