YM-155
货号：
11490-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 11490-1mg |
| 描述 | Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM-155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter.1 It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM.2 At concentrations up to 100 nM, YM-155 has little effect on expression levels of other IAP- or Bcl-2-related proteins.2 YM-155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.2,3 |
| 别名 | Sepantronium bromide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nakamura, N.,Yamauchi, T.,Hiramoto, M., et al. Interleukin enhancer-binding factor 3/NF110 is a target of YM155, a suppressant of survivin. Molecular & Cellular Proteomics 11(7), (2012).
2.Nakahara, T.,Takeuchi, M.,Kinoyama, I., et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Research 67(17), 8014-8021 (2007).
3.Na, Y.S.,Yang, S.J.,Kim, S.M., et al. YM155 induces EGFR suppression in pancreatic cancer cells. PLoS One 7(6), (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 443.3 |
| 分子式 | C20H19N4O3 • Br |
| CAS号 | 781661-94-7 |
| 稳定性 | ≥ 2 years |
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