| 货号 | 11425-1mg |
| 描述 | Alamethicin is an antibiotic peptide belonging to a class of membrane active peptides of fungal origin called peptaibols.1 It contains an unusual amphiphilic amino acid, 2-aminoisobutyric acid, which strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell membranes.1 Alamethicin is often used to study ion channel assembly, voltage gating, and peptide-membrane interactions.2,3,4,5 Alamethicin is also widely used as agent to induce various physiological and defense responses in eukaryotic cells including plants.1 |
| 别名 | Antibiotic U-22324; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Maischak, H.,Zimmermann, M.R.,Felle, H.H., et al. Alamethicin-induced electrical long distance signaling in plants. Plant Signal.Behav. 5(8), 988-990 (2010). 2.Kessel, A.,Cafiso, D.S. and Ben-Tal, N. Continuum solvent model calculations of alamethicin-membrane interactions: Thermodynamic aspects. Biophysical Journal 78(2), 571-583 (2000). 3.Pan, J.,Tristram-Nagle, S. and Nagle, J.F. Alamethicin aggregation in lipid membranes. Journal of Membrane Biology 231(1), 1-36 (2009). 4.Jones, L.R.,Maddock, S.W. and Besch, H.R., Jr. Unmasking effect of alamethicin on the (Na+,K+)-ATPase, β-adrenergic receptor-coupled adenylate cyclase, and cAMP-dependent protein kinase activities of cardiac sarcolemmal vesicles. The Journal of Biological Chemisty 255(20), 9971-9980 (1980). 5.Walsky, R.L.,Bauman, J.N.,Bourcier, K., et al. Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. Drug Metabolism and Disposition 40(5), 1051-1065 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 1964.3 |
| 分子式 | C92H150N22O25 |
| CAS号 | 27061-78-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |