| 货号 | 11328-1mg |
| 描述 | Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments.1 By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.2,3,4 Cytochalasin B is broadly used in cytological studies involving any of these many processes that depend on actin polymerization.5,6,7 |
| 别名 | NSC 107658;Phomin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Theodoropoulos, P.A.,Gravanis, A.,Tsapara, A., et al. Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochemical Pharmacology 47(10), 1875-1881 (1994). 2.Steinberg, M.S. and Wiseman, L.L. Do morphogenetic tissue rearrangements require active cell movements? The reversible inhibition of cell sorting and tissue spreading by cytochalasin B. Journal of Cell Biology 55, 606-615 (1972). 3.Spudich, J.A. and Lin, S. Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement/microfilaments/rabbit striated muscle). Proc.Nat.Acad.Sci.USA 69(2), 442-446 (1972). 4.Estensen, R.D. and Plagemann, P.G.W. Cytochalasin B: Inhibition of glucose and glucosamine transport. Proc.Nat.Acad.Sci.USA 69(6), 1430-1434 (1972). 5.Snezhko, A.,Barlan, K.,Aranson, I.S., et al. Statistics of active transport in Xenopus melanophores cells. Biophysical Journal 99, 3216-3223 (2010). 6.Yu, Y.,Dumollard, R.,Rossbach, A., et al. Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation. Journal of Cellular Physiology 224(3), 672-680 (2010). 7.Yu, Y.,Maguire, T.G. and Alwine, J.C. Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection. Journal of Virology 85(4), 1573-1580 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 479.6 |
| 分子式 | C29H37NO5 |
| CAS号 | 14930-96-2 |
| 稳定性 | ≥ 2 years |
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