| 货号 | 11323-1g |
| 描述 | Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.1,2 It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.3,4 Sodium 4-phenylbutyrate has been tested in clinical trials for the treatment of recurrent malignant gliomas and myelodysplastic syndrome and has long been used for treating urea cycle disorders.5 |
| 别名 | Benzenebutanoic acid;NSC 657802;TriButyrate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Stewart, G.A.,Ridscale, R.,Martin, E.P., et al. 4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein-C. American Journal of Respiration, Cell, and Molecular Biology 47(3), 324-331 (2012). 2.Bradbury, N.A. Focus on "sodium 4-phenylbutyrate downregulates Hsc70: Implications for intracellular trafficking of ΔF508-CFTR". American Journal of Physiology.Cell Physiology 278(2), 257-258 (2000). 3.Lu, Q.,Wang, D.S.,Chen, C.S., et al. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. Journal of Medicinal Chemistry 48, 5530-5535 (2005). 4.Ammerpohl, O.,Trauzold, A.,Schniewind, B., et al. Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. British Journal of Cancer 96(1), 73-81 (2007). 5.Griffiths, E.A. and Gore, S.D. DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin.Hematol. 45(1), 23-30 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 186.2 |
| 分子式 | C10H11O2 • Na |
| CAS号 | 1716-12-7 |
| 稳定性 | ≥ 2 years |
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