| 货号 | 11173-1mg |
| 描述 | Glucose transporter 1 (Glut1) is an inducible carrier of pentoses and hexoses, including glucose. STF-31 is an inhibitor of Glut1 (IC50 = ~1 µM) that blocks glucose uptake.1 It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress Glut1.1 Although STF-31 binds Glut1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces Glut1 expression.1,2,3 STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chan, D.A.,Sutphin, P.D.,Nguyen, P., et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci.Transl.Med. 3(94), 1-9 (2011). 2.Adams, D.J.,Ito, D.,Rees, M.G., et al. NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chemical Biology 9(10), 2247-2254 (2014). 3.Garten, A.,Petzold, S.,Körner, A., et al. Nampt: Linking NAD biology, metabolism, and cancer. Trends in Endocrinology and Metabolism 20(3), 130-138 (2009). 4.Boheler, K.R.,Bhattacharya, S.,Kropp, E.M., et al. A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets. Stem Cell Reports 3, 185-203 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 423.5 |
| 分子式 | C23H25N3O3S |
| CAS号 | 724741-75-7 |
| 稳定性 | ≥ 2 years |
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