4-Quinolone-3-Carboxamide Furan CB2 Agonist
货号：
11094-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 11094-1mg |
| 描述 | Agonists of the peripheral cannabinoid (CB) receptor CB2 may have antinociceptive and anti-inflammatory effects, as well as prevent osteoporosis.1,2 4-Quinolone-3-carboxamide Furan CB2 Agonist is a high-affinity ligand of CB2(Ki = 8.5 nM) with little affinity for CB1(Ki >10,000 nM).3 This compound demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB2-selective antagonist, AM630 (Item No. 10006974).3 |
| 别名 | 4Q3C CB2Agonist; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Guindon, J. and Hohmann, A.G. Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain. British Journal of Pharmacology 153, 319-334 (2008).
2.Idris, A.I.,vant Hof, R.J.,Greig, I.R., et al. Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nature Medicine Advance Online Publication, 1-6 (2005).
3.Pasquini, S.,De Rosa, M.,Pedani, V., et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. Journal of Medicinal Chemistry 54, 5444-5453 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 488.6 |
| 分子式 | C30H36N2O4 |
| CAS号 | 1314230-75-5 |
| 稳定性 | ≥ 2 years |
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