Niclosamide
货号：
10649-25g 基本售价：
490.0 元 规格：
25 g
产品信息
概述| 货号 | 10649-25g |
| 描述 | Niclosamide is a salicylanilide compound with antihelminthic actions.1 It specifically inhibits the signal transducer and activator of transcription 3 (STAT3) with an IC50 value of 0.25 μM. It does not decrease the level or activity of the related STAT1, STAT5, JAK, or Src kinases. Through its effects on STAT3, niclosamide inhibits the proliferation and colony formation of Du145 prostate cancer cells, which have constitutively active STAT3, with IC50 values of 0.7 and 0.1 μM, respectively.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Balgi, A.D.,Fonseca, B.D.,Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4(9), 1-15 (2009).
2.Ren, X.,Duan, L.,He, Q., et al. Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Med.Chem.Lett. (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 327.1 |
| 分子式 | C13H8Cl2N2O4 |
| CAS号 | 50-65-7 |
| 稳定性 | ≥ 2 years |
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